Seroprevalence against Toscana virus in Spain: The case of the autonomous community of Madrid

Background & objectives: The Toscana virus (TOSV) is a neurotropic arbovirus that is transmitted through the bite of some Phlebotomus species. In 2009, the largest outbreak of leishmaniasis described so far in Europe, occurred in the Autonomous Community of Madrid, Spain, which was related to the population increase of P. perniciosus in this region. Methods: A seroprevalence study was conducted to determine the circulation of TOSV among the population of this geographic area. A total of 516 sera were collected in two different stages: 2007 (before the leishmaniasis outbreak) and 2018–19 (representative of the current situation). In the sera, presence of IgG antibodies against TOSV was determined by commercial ELISA. Results: The overall seroprevalence was 34.5%. The anti-TOSV IgG level was significantly higher in the samples collected in 2007 (41.5%) than 2018–19 (27.3%). Interpretation & conclusion: The results of this study show a very active TOSV circulation in the region that is greater than expected. The lower seroprevalence figures in 2018–19 may be related to the vector and environmental control measures that were put in place as a result of the leishmaniasis outbreak of 2009. This highlights the importance of such strategies to reduce the incidence of TOSV infection and other vector-borne diseases.

Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality / 대한뇌졸중학회지

Background@#and Purpose Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. @*Methods@#We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). @*Results@#There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. @*Conclusions@#During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT.

Bloodstream infections in cancer patients / Artículo original

Resumen Las infecciones del torrente sanguíneo (ITS) son una importante causa de morbimortalidad en pacientes oncológicos. Los objetivos del estudio fueron evaluar las características de las ITS en pacientes con neoplasia hematológica (NH) y sólida (NS) en un estudio retrospectivo realizado en dos hospitales, entre 2009 y 2016. Fueron incluidos todos los episodios de ITS en adultos con neoplasias activas, excepto cáncer de piel no melanoma. Fueron identificados 467 episodios de bacteriemia y 16 de fungemia. Un total de 200 (41.4%) bacteriemias ocurrieron en pacientes con NH y 283 (58.6%) en pacientes con NS. Las NS y NH más frecuentes fueron cáncer de colon (18.7%) y linfoma no Hodgkin (27%), respectivamente. Los principales factores de riesgo de ITS fueron el antecedente de procedimiento quirúrgico para NS y quimioterapia en los 30 días previos y uso de catéter venoso central para NH. Las infecciones fueron adquiridas principalmente en el medio intrahospitalario y la presentación más frecuente fue la bacteriemia sin foco, fundamentalmente en NH (38.0% vs. 20.8%, p < 0.001). En un total de 336 (69.5%) aislamientos predominaron bacilos Gram negativos (BGN) sobre cocos Gram positivos (CGP) sin diferencias entre grupos. Escherichia coli fue el BGN más frecuente en NS (24.7%) y NH (20.5%). El CGP más frecuente fue Staphylococcus aureus. El 15% y el 18% de los aislamientos fue multirresistente en NS y NH, respectivamente. La mortalidad global fue 40.5% en pacientes con NH y 37.5% en pacientes con NS. La mayoría de las muertes ocurrió en los primeros 30 días.

Abstract Bloodstream infections (BI) are an important cause of morbidity and mortality in cancer patients. A retrospective study was performed in two hospitals aimed to evaluate characteristics of BI episodes occurred in adult patients with hematologic (HN) and solid (SN) neoplasia other than non-melanoma skin cancers in the period 2009-2016. A total of 467 episodes of bacteremia and 16 of fungemia were identified. A total of 200 (41.4%) bacteremias occurred in patients with HN and 283 (58.6%) in patients with SN. The most frequent SN and HN were colon cancer (18.7%) and non-Hodgkin lymphoma (27%), respectively. The main risk factors for BI were a previous surgical procedure in SN and chemotherapy in the previous 30 days and use of central venous catheter in HN. Infections were mainly acquired in the hospital environment and the most frequent presentation was bacteremia without focus, mostly in HN (38% vs. 20.8%, p < 0.001). Gram negative bacilli (GNB) were isolated in 336 (69.5%) episodes and predominated over Gram positive cocci (GPC) in both groups. Escherichia coli was the most frequent GNB isolated in both SN (24.7%) and HN patients (20.5%). The most frequent GPC was Staphylococcus aureus. Multidrug-resistance was found in 15% of the isolates in SN and 18% in HN. The overall mortality was 40.5% in patients with HN and 37.5% in patients with SN, with the majority of deaths occurring in the first 30 days.

Obesity and Depression: Its Prevalence and Influence as a Prognostic Factor: A Systematic Review

Objective@#Depression and obesity are two conditions with great impact over global health. This is mainly due to their high prevalence and the morbidity and mortality associated to both. The main aim of the present systematic review is to study the association between obesity and depression and the prognostic implications derived from it. @*Methods@#A literature review was performed in the PUBMED database. 18 articles were found (9 cross-sectional studies, 6 longitudinal studies and 3 clinical trials), which were reviewed by critical reading after which a summary of the main conclusions was written. @*Results@#These selected articles confirmed that there is indeed a link between depression and obesity, although there are doubts as to the significance of this relationship. Depression is a risk factor for obesity, especially atypical depression and in African-American adolescent males. Obesity is a risk factor for depression, especially in women and for recurrent depressive disorder. The comorbidity between obesity and depression is a risk factor for a bad prognosis illness. @*Conclusion@#The relationship between both disorders has been analysed in scientific literature, obtaining significant associations but also contradictory results. The most current data demonstrates that there is a relationship between both entities, although there is no unanimity when it comes to establishing the meaning of this association.

Dual endovascular repair (coils and stent) of a true aneurysm of the gastroduodenal artery / Reparo endovascular duplo (molas e stent) de aneurisma verdadeiro da artéria gastroduodenal

Abstract We report a case of an asymptomatic gastroduodenal artery aneurysm diagnosed in a 39 year-old woman. An abdominal ultrasound study showed an aneurysmal dilatation of the gastroduodenal artery with 2 x 2 cm diameter. To confirm this finding, she then underwent a computed tomography scan of the abdomen and pelvis that showed a saccular aneurysm of the gastroduodenal artery. A dual endovascular approach was used to exclude the aneurysm by stent-assisted coil embolization. Complete exclusion of the aneurysm sac was confirmed on final angiography. She was discharged from the hospital on postoperative day 1.

Resumo Relatamos um caso de aneurisma de artéria gastroduodenal assintomático diagnosticado em uma mulher de 39 anos. Uma ultrassonografia abdominal mostrou uma dilatação aneurismática associada à artéria gastroduodenal com 2 x 2 cm de diâmetro. Para confirmar esse achado, foi realizada uma tomografia computadorizada do abdome e da pelve, que revelou um aneurisma sacular da artéria gastroduodenal. Uma abordagem endovascular dupla foi utilizada para exclusão do aneurisma mediante embolização com molas assistida por stent. A exclusão completa do saco aneurismático foi confirmada na angiografia final. A paciente recebeu alta hospitalar no primeiro dia de pós-operatório.

Biopsy Path Contamination in Primary Bone Sarcomas / Contaminação do trajeto de biópsia em sarcomas primários ósseos

Abstract Objective To determine the incidence of contamination of the biopsy pathway in patients with primary bone sarcomas, as well as the clinical characteristics that influenced this outcome. Materials and Methods The anatomopathological reports of the patients who were treated by the Orthopedic Oncology Sector of the Orthopedic and Traumatology Department of this institution were retrospectively evaluated. Results Of the 148 patients included for evaluation in the present study, only 1 presented contamination by neoplastic cells in his biopsy pathway. Conclusion The bone biopsy procedure in patients with primary bone sarcomas presents great safety regarding pathway contamination when performed in specialized centers that treat this type of pathology.

Resumo Objetivo Determinar a incidência da contaminação do trajeto de biópsia nos pacientes com sarcomas primários ósseos, bem como as características clínicas que influenciaram neste desfecho. Método Foram avaliados retrospectivamente os laudos anatomopatológicos de pacientes tratados pelo Serviço de Oncologia Ortopédica do Departamento de Ortopedia e Traumatologia dessa instituição. Resultado Dentre os 148 pacientes incluídos no presente estudo, apenas um apresentou contaminação por células neoplásicas em seu trajeto de biópsia. Conclusão O procedimento de biópsia óssea em pacientes com sarcomas primários ósseos apresenta grande segurança no quesito contaminação quando feito em centros especializados no tratamento dessas patologias.

Características clínicas, epidemiológicas y riesgo obstétrico de las pacientes con preeclampsia-eclampsia / Clinical, epidemiological and obstetric risk characteristics of patients with preeclampsia-eclampsia

Introducción: la preeclampsia es un trastorno multisistémico cuyos criterios clínicos no han cambiado en la última década. De acuerdo con la OMS, la incidencia de preeclampsia oscila entre el 2 y 10% del total de embarazos, y su prevalencia es siete veces mayor en los países en vías de desarrollo que en los países desarrollados. Objetivo: describir las características epidemiológicas, clínicas y antecedentes obstétricos de las pacientes con diagnóstico de preeclampsia-eclampsia de la unidad de cuidados intensivos adultos (UCIA). Métodos: estudio descriptivo transversal retrospectivo, se incluyeron 20 expedientes clínicos de las pacientes entre 13 y 45 años de edad, con embarazo ≥ 20 semanas de gestación de la unidad de cuidados intensivos adultos, con diagnóstico confirmado de preeclampsia-eclampsia. Se aplicó un instrumento diseñado para el estudio. Resultados: edad promedio de 28.45 ± 6.57 años. El 55% presentó preeclampsia severa y síndrome de HELLP el 60%. Con estancia en la UCIA de 2.4 ± 1.43 días. Conclusiones: aunque los datos no fueron suficientes para documentar, la proporción de pacientes con hipertensión arterial y antecedentes de preeclampsia, así como, hipertensión arterial de comorbilidad fue superior a lo referido en un estudio con embarazadas en Colombia de 12.4%.

Introduction: Preeclampsia is a multisystem disorder whose clinical criteria have not changed in the last decade. According to the WHO, the incidence of preeclampsia varies between 2% and 10% of all pregnancies, and its prevalence is seven times higher in developing countries than in developed countries. Objective: To describe the epidemiological and clinical characteristics and obstetric history of patients diagnosed with preeclampsia-eclampsia of the adult intensive care unit (ICU). Methods: A retrospective cross-sectional descriptive study, 20 clinical files were included of patients between 13 and 45 years of age, with pregnancy ≥ 20 weeks gestation of the adult intensive care unit, with a confirmed diagnosis of preeclampsia- eclampsia. An instrument designed for the study was applied. Results: Average age 28.45 ± 6.57 years. 55% presented severe preeclampsia and HELLP syndrome 60%. With a stay in the UCIA of 2.4 ± 1.43 days. Conclusions: Although the data were not enough to document, the proportion of patients with hypertension and a history of preeclampsia, as well as, comorbidity hypertension were higher than that reported in a study with pregnant women in Colombia of 12.4%.

Primary care nurses' cognitive and attitudinal ability in leprosy control / Aptidões cognitivas e atitudinais do enfermeiro da atenção básica no controle da hanseníase / Aptitudes cognitivas y actitudinales del enfermero de la atención básica en el control de la hanseniasis

Objetivo investigar as aptidões cognitivas e atitudinais dos enfermeiros da Atenção Básica para o controle da hanseníase. Método estudo descritivo quantitativo, realizado entre janeiro e dezembro de 2012, com 101 enfermeiros dos sete distritos sanitários de São Luís, Maranhão, Brasil. Utilizou-se um questionário estruturado com cinco categorias de respostas, ordenadas de acordo com a escala de Likert. Às respostas foram atribuídos escores que levaram à formação de um conceito (excelente; muito bom; bom; regular; ruim). Resultados consideraram-se capacitados 71,2%, porém 63,3% não se sentem aptos para desenvolver ações de prevenção de incapacidades e 83,1% seguiam o protocolo padronizado. Quanto às aptidões cognitivas e atitudinais, a maioria apresentou conceito muito bom (58,4% e 67,3%, respectivamente). Conclusão os enfermeiros, segundo a classificação adotada, possuem boas aptidões cognitivas e atitudinais. No entanto, as capacitações em hanseníase não atendem às reais necessidades de conduta desses profissionais nas ações de diagnóstico e tratamento do agravo.

Objetivo investigar las aptitudes cognitivas y actitudinales de los enfermeros de la Atención Básica para el control de la hanseníasis. Método estudio descriptivo cuantitativo, realizado entre enero y diciembre de 2012, con 101 enfermeros de los siete distritos sanitarios de São Luís, Maranhão, Brasil. Se utilizó un cuestionario estructurado con cinco categorías de respuestas, ordenadas de acuerdo con la escala de Likert. Las respuestas fueron atribuidos puntos que llevaron a la formación de un concepto (excelente; muy bueno; bueno; regular; malo). Resultados se consideraron capacitados 71,2%, sin embargo 63,3% no se sienten aptos para desarrollar acciones de prevención de incapacidades y 83,1% seguían el protocolo padronizado. Sobre las aptitudes cognitivas y actitudinales, la mayoría presentó concepto muy bueno (58,4% y 67,3%, respectivamente). Conclusión los enfermeros, según la clasificación adoptada, poseen buenas aptitudes cognitivas y actitudinales. Sin embargo, las capacitaciones en hanseníasis no atienden a las reales necesidades de conducta de esos profesionales en las acciones de diagnóstico y tratamiento del problema.

Objective to investigate Primary Care nurses’ cognitive and attitudinal abilities for leprosy control. Method this is a quantitative descriptive study, conducted between January and December 2012, with 101 nurses from the seven sanitary districts of São Luis, Maranhão, Brazil. A structured questionnaire was used with five categories of answers, ranked according to the Likert scale. Scores were assigned scores to the answers, which led to the formation of a concept (excellent, very good, good, fair, poor). Results 71.2% considered themselves capable, but 63.3% did not feel able to develop disability prevention actions and 83.1% followed the standardized protocol. Regarding cognitive and attitudinal abilities, the majority presented a very good concept (58.4% and 67.3%, respectively). Conclusion nurses, according to the adopted classification, have good cognitive and attitudinal abilities. However, training in leprosy does not meet the real needs of these professionals in the actions of diagnosis and treatment of the disease.

O social e o cultural na perspectiva histórico-cultural: tendências conceituais contemporâneas / Lo social y lo cultural en la perspectiva histórico cultural: tendencias conceptuales contemporáneas / The social and the cultural on the perspective of contemporary trends on concepts

Este artigo problematiza o uso dos conceitos "social" e "cultural", apensos à Psicologia, como categorias teóricas centrais para pensar implicações que decorrem dos diversos significados que eles podem assumir nas práticas psicológicas. Trazemos questões que versam sobre a relação desses conceitos na teoria histórico-cultural, já que concepções diferentes têm reverberado historicamente na tessitura da práxis psicológica. É um estudo bibliográfico no qual tratamos do significado que autores contemporâneos atribuem às categorias "social" e "cultural" e tecemos relações entre essas ideias e a construção teórico-metodológica proposta por Vygotsky. Observamos que a ligação entre tais categorias se faz principalmente pela compreensão da dimensão histórica, uma vez que é a história que faz surgir, no social, a construção da cultura. Este estudo se faz relevante por trazer elementos úteis para problematização e compreensão mais consistente dos termos "social" e "cultural" e das práxis a eles associadas

This article discusses the use of "social" and "cultural" concepts, attached to This article discusses the use of 'social' and 'cultural' concepts, attached to Psychology, as central theoretical categories to think about implications which arise from the various meanings that they can have on psychological practices. We bring questions that concern the relation on those concepts on the Historical-cultural theory, once divergent conceptions have reverberated historically on the fabric on psychological praxis. This is a bibliographical study, in which we deal with the meaning that contemporary authors have attributed to the 'social' and 'cultural' categories and we weave relations between those categories and the theoretical and methodological construction purposed by Vygotsky. We have observed that the link between such categories is mainly due to the comprehension of the historical dimension, once the history that emerges, on the social, the construction of culture. This study is relevant for citing useful elements to the discussion and to a more consistent comprehension of the terms "social" and "cultural" and of the praxis associated to those

En este artículo se analiza el uso de los conceptos "social" y "cultural", propios de la Psicología, como categorías teóricas centrales para pensar acerca de las implicaciones que se derivan de los diferentes significados que ellos pueden asumir en las prácticas psicológicas. Abordamos cuestiones que tratan sobre la relación de estos conceptos en la teoría históricocultural, ya que concepciones han repercutido históricamente en la práctica psicológica. Se trata de un estudio bibliográfico en el cual tratamos del significado que autores contemporáneos atribuyen a las categorías "social" y "cultural" y entrelazamos relaciones entre estas ideas y la construcción teórico-metodológica propuesta por Vygotsky. Observamos que la relación entre estas categorías se realiza principalmente por la comprensión de la dimensión histórica, ya que es la historia la que hacer surgir, en lo social, la construcción de la cultura. Este estudio es relevante por traer elementos útiles para la problematización y comprensión más consistente de los términos "social" y "cultural" y de la praxis asociada a ellos

A infância em Piaget e o infantil em Freud: temporalidades e moralidades em questão / Childhood in Piaget and infancy in Freud: temporality and moralities / La infancia en Piaget y el infantil en Freud: temporalidad y moralidades

O presente artigo propõe uma abordagem comparativa entre as noções de infância em Jean Piaget e de infantil em Sigmund Freud, tomando como conceitos básicos a noção de tempo e de moral em ambos os autores. Sustenta-se ser possível afirmar, a partir de uma leitura da epistemologia genética, que a infância vai-se transformando à medida que agimos e conhecemos de acordo com estruturas cognitivas operatórias. No entanto, segundo a psicanálise, é possível nos remeter ao infantil, presente também na vida adulta. O infantil escapa à racionalidade que subjaz àquela noção de estrutura piagetiana. A permanência do infantil é fonte das experiências criativas e da instauração de um movimento permanente de subjetivação.

This article proposes a comparative approach between childhood notions of Jean Piaget and infancy in Sigmund Freud, it takes as basic concepts the notion of time and moral in both authors. It claims to be possible to state, from a reading of genetic epistemology, that childhood will be transformed as we act and we know according to operative cognitive structures. However, according to psychoanalysis, it is possible to refer to infancy, also present in adulthood. The infancy escapes the rationality that underlies to that notion of Piaget's structure. The permanence of the infancy is a source of creative experiences and the establishment of a permanent movement of subjectivity.

El presente artículo propone un abordaje comparativo entre las nociones de infancia en Jean Piaget y de infantil en Sigmund Freud, tomando como conceptos básicos la noción de tiempo y de moral en ambos autores. Se sostiene ser posible afirmar, a partir de una lectura de la epistemología genética, que la infancia se va transformando a medida que actuamos y conocemos de acuerdo con estructuras cognitivas operatorias. Sin embargo, según el psicoanálisis, es posible remeternos al infantil, presente también en la vida adulta. El infantil escapa a la racionalidad que refuerza a aquella noción de estructura piagetiana. La permanencia del infantil es fuente de las experiencias creativas y de la instauración de un movimiento permanente de subjetivación.

Expansão de cursos de psicologia no Ceará: formação docente a partir de pesquisa documental / The expansion of psychology courses in Ceará studying the teacher's training through the documentary research

O relatório estuda a expansão de cursos de Psicologia no Ceará e os programas de disciplinas estudadas, tendo como objetivo desvelar conhecimentos acerca das práticas docentes e propor ações que acrescentem qualidade à expansão. A pergunta axial que a pesquisa tenta responder refere-se ao perfil dos currículos apresentados nos cursos, constantes nos planos das disciplinas obrigatórias entre o segundo e o sexto semestre no que tange aos objetivos na formação profissional, à metodologia do ensino, à avaliação da aprendizagem. A pesquisa constitui-se como documental, retirando da Análise de conteúdos os procedimentos metodológicos para inferir categorias que ajudem a conhecer práticas no ensino da Psicologia. Os resultados encontrados na pesquisa foram analisados sob o prisma da Pedagogia Crítica. Constata-se que aparecem programas de disciplinas consultadas muito bem elaborados. Mas, fica patente a necessidade de estudo posterior ouvindo professores porque nem sempre o que está escrito nos programas corresponde à prática docente. Propõe-se como desafio didático a revitalização dos programas de ensino de psicologia e superar sua cristalização no quod scriptum, scriptum est, para acompanhar a dinamicidade das configurações societárias e das subjetividades contemporâneas.

The report is a study about the expansion of Psychology courses in Ceará and the corresponding subjects of their academic programs, aiming to unveil knowledge about teaching practices and proposing actions that add quality to this expansion. The main question that this research attempts to answer refers to the profile of the curriculum presented in the courses which is part of compulsory subjects of the studying programs of the period between the second and sixth academic semester with respect to the professional formation, teaching methodology and assesment of the students' learning level. It is a documentary research that uses the content analysis as methodological procedures in order to infer categories that help to know the practices of the psychological education. The results in the survey were analyzed from the perspective of the Critical Pedagogy. Disciplines programs seem to be very well elaborated. But it is clear the need for further studies that include in their methodolgy the listening to teachers because these considered programs do not correspond to the actual teaching practices. It is proposed as an educational challenge to revitalize these psycholgy teaching programs so that they can go beyond their crystallization in the form of a quod scriptum, scriptum est and in order to follow the dynamics of societal settings and contemporary subjectivities.

The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients / 부인종양

OBJECTIVE: We aimed to evaluate the prognostic and predictive value of the nucleotide excision repair-related gene GTF2H5, which is localized at the 6q24.2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients. METHODS: In order to test if protein levels of GTF2H5 are associated with patients' outcome, we performed GTF2H5 immunohistochemical staining in 139 high-grade serous ovarian carcinomas included in tissue microarrays. Upon stratification of cases into high- and low-GTF2H5 staining categories (> and < or = median staining, respectively) Kaplan-Meier and log-rank test were used to estimate patients' survival and assess statistical differences. We also evaluated the association of GTF2H5 with survival at the transcriptional level by using the on-line Kaplan-Meier plotter tool, which includes gene expression and survival data of 855 high-grade serous ovarian cancer patients from 13 different datasets. Finally, we determined whether stable short hairpin RNA-mediated GTF2H5 downregulation modulates cisplatin sensitivity in the SKOV3 and COV504 cell lines by using cytotoxicity assays. RESULTS: Low expression of GTF2H5 was associated with longer 5-year survival of patients at the protein (hazard ratio [HR], 0.52; 95% CI, 0.29 to 0.93; p=0.024) and transcriptional level (HR, 0.80; 95% CI, 0.65 to 0.97; p=0.023) in high-grade serous ovarian cancer patients. We confirmed the association with 5-year overall survival (HR, 0.55; 95% CI, 0.38 to 0.78; p=0.0007) and also found an association with progression-free survival (HR, 0.72; 95% CI, 0.54 to 0.96; p=0.026) in a homogenous group of 388 high-stage (stages III-IV using the International Federation of Gynecology and Obstetrics staging system), optimally debulked high-grade serous ovarian cancer patients. GTF2H5-silencing induced a decrease of the half maximal inhibitory concentration upon cisplatin treatment in GTF2H5-silenced ovarian cancer cells. CONCLUSION: Low levels of GTF2H5 are associated with enhanced prognosis in high-grade serous ovarian cancer patients and may contribute to cisplatin sensitization.

Structural and Functional Outcomes in Chronic Central Serous Chorioretinopathy Treated with Photodynamic Therapy

PURPOSE: To study the retinal pigment epithelium (RPE) and retinal alterations in chronic central serous chorioretinopathy treated with photodynamic therapy, and its correlation with functional parameters such as best-corrected visual acuity (BCVA) and contrast sensitivity (CS). METHODS: Retrospective, noncomparative, consecutive evaluation by optical coherence tomography and its correlation with BCVA and CS in 31 eyes of 26 patients. RESULTS: In all affected patients, 88.5% were male with a mean age of 42.9 years. The right eye was involved in 64.5% of cases, bilateral in 19% and 73.9% were hyperopic (spherical refraction between 0 and +5.0 diopters). Of these cases, 51.5% had peri-RPE abnormalities, 17.3% hyperreflective substances at RPE, 19.4% RPE atrophy, 55.3% foveolar atrophy, 3.1% pigment epithelial detachment, 5.2% subretinal fluid persistence, 8.3% fibrin deposits, 68.4% photoreceptor inner and outer segment line interruption and 31.1% external limiting membrane interruption. CONCLUSIONS: Time evolution and number of outbreaks were related to the decrease in foveal and chorodial thickness and in those with worse BCVA and CS. RPE abnormalities and atrophy were related to the age of onset of symptoms. Photoreceptor elongation has been correlated with poor BCVA and inner and outer segment line destructuring and interruption with poor CS.

Postural assessment of patients with non-conventional knee endoprosthesis

Objective: To investigate the correlation between the sagittal and frontal alignment and possible postural asymmetries found in patients submitted to total knee stent placement for osteosarcoma. Methods: Twenty two individuals were divided into two groups according to tumor location: femur group (13 patients) and tibia group (nine patients), who were evaluated through postural analysis software (SAPO). Results: No statistically significant difference was found between groups, supporting previous result showing that both groups present the same postural asymmetries. Conclusion: We conclude that both groups have the same postural imbalances, especially the knee of the affected limb that presents hyperextension and center of gravity shifted anteriorly and laterally to the non-affected limb, indicating changes in weight bearing and influencing the gait pattern and balance. Level of Evidence II, Prospective Comparative Study. .

As desrazões do esclarecimento / Unreasons of the enlightenment / Las desraciones del esclarecimiento / Les déraisons de la raison

O presente estudo busca analisar a contribuição da Dialética do Esclarecimento de Theodor Adorno e Max Horkheimer para a crítica da razão moderna. Empreendemos uma compreensão da crítica estabelecida por esses autores ao Esclarecimento, expondo a crítica ao Esclarecimento em sentido lato, com a pretensão de estabelecer um paralelo entre a Razão moderna Instrumental e a Razão mercantil moderna. O objetivo é o de discernir no Esclarecimento traços que só se desenvolveram e se diferenciaram na modernidade capitalista. Deste modo, realizamos uma análise crítica que parte da hipótese de que o desenvolvimento da razão moderna positiva enquanto epistemologia - tal como é exposta pelos autores supracitados - tem como pano de fundo tácito o desenvolvimento da lógica da mercadoria, a lógica tautológica e autotélica da valorização incessante do dinheiro (Marx). A análise dessa relação visa explicitar elementos acerca da subjetividade contemporânea e das novas formas de dominação implícitas, próprias da Razão mercantil moderna.

This study seeks to analyse the contribution of Theodor Adorno and Max Horkheimer to the critique of modern reason in the Dialectic of Enlightenment. It tries to undertake a critical understanding about the concept of Enlightenment, by exposing his critique in a broad sense. It intents to draw a parallel between the modern Instrumental reason and the modern mercantile reason, i.e., it tries to discern the traces of Enlightenment that only developed and differentiated in the capitalist modernity. Thus it undertakes a critical analysis about the hypothesis that considers the development of positive modern reason as epistemology - such as is exposed by the authors mentioned above - but that has the tacit background: the development of logic of the commodity, the autotelic logic of the incessant valorization of the money (Marx). The analysis aims to clarify this relationship on elements of contemporary subjectivity and new forms of domination implied, Reason's own modern market.

Este estudio busca hacer un análisis de la contribución de la Dialéctica de la Ilustración de Theodor Adorno y Max Horkheimer a la crítica de la razón moderna. Intentaremos una comprensión de la crítica que estos autores establecieron mediante la exposición de la crítica de la Ilustración en el sentido más amplio, esperando establecer un paralelo entre la Razón Instrumental moderna y la Razón mercantil moderna. El intento es discernir en el Esclarecimiento huellas que sólo se desarrollaron y diferenciaron en la modernidad capitalista. Por lo tanto vamos a realizar un análisis crítico sobre el supuesto de que el desarrollo de la razón moderna positivista como epistemología -como es expuesta por los autores mencionados anteriormente- tiene por base el desarrollo de la lógica tácita de la mercancía, la lógica autotélica, tautológica de la valoración incesante del dinero (Marx). El análisis de esta relación busca explicar elementos sobre la subjetividad contemporánea y de nuevas formas de dominación implícitas, inerentes a la Razón mercantil moderna.

Cette étude cherche à analyser la contribution de La Dialectique de la Raison de Theodor Adorno et Max Horkheimer pour la critique de raison moderne. On entreprît une interprétation de la critique de la Raison établie par ces auteurs en exposant une critique à la Raison au sens large, pour ensuite essayer d'établir un parallèle entre la Raison moderne Instrumentale et la Raison marchande moderne. Le but est de discerner au coeur de la Raison des traits qui ne se sont épanouis et ne se sont démarqués que dans l'époque moderne, l'époque capitaliste. Ainsi, notre hypothèse critique est que le développement de la raison moderne positive en tant qu'épistémologie - telle qu'elle est exposée par les auteurs cités - s'assied implicitement sur le développement de la raison marchande, une logique tautologique e autotélique de la valorisation incessante de l'argent (Marx). L'analyse de ce rapport vise à dévoiler quelques éléments propre à la subjectivité contemporaine et de nouvelles formes de dominations plus subtiles, propres à la Raison marchande moderne.

Filiações epistemológicas em projetos de mestrado em Psicologia: estudo sobre os autores que os fundamentam / Epistemological links in psychology master projects: a study about the authors that underlie them

O aumento da procura por cursos de pós-graduação no Ceará suscita o interesse pela investi-gação de aspectos concernentes aos mesmos. O presente artigo investiga as referências biblio-gráficas utilizadas, em projetos de mestrado, pelos candidatos que se submeteram à seleção do mestrado em Psicologia em universidade situada na cidade de Fortaleza (CE), no período de 2006 a 2010. Trata-se de pesquisa bibliográfica/documental, cujo acervo consta de livros e documentos: fontes de estudo sobre a Psicologia ­ livros-texto, livros sobre epistemologia da Psicologia, livros-roteiro ­ e 52 projetos de mestrado. Recorremos aos livros para definir o que designamos por "autores basilares" na configuração da ciência psicológica ­ fundadores de teo-rias psicológicas ou fomentadores reconhecidos das mesmas. Os 52 projetos de mestrado foram analisados quanto às referências bibliográficas utilizadas como fundamentação teórica, as quais foram comparadas com aquelas citadas nos livros-texto, livros sobre epistemologia da Psicologia e livros-roteiro. Isso nos permitiu identificar a proporcionalidade entre a utilização de "autores basilares" e a utilização de "autores emergentes", aqueles que começam a ser referenciados em trabalhos científicos, mas não têm, ainda, contribuições consolidadas para o desenvolvimento da Psicologia. Os resultados da pesquisa mostram que os candidatos à Pós-Graduação em Psicologia mantêm equilíbrio na fundamentação teórica dos projetos, pois recorrem preferencialmente a "autores basilares" da Psicologia e de outras ciências, bem como, promovem o aparecimento de novos nomes no cenário científico psicológico, os "autores emergentes".

The increase in demand for post-graduate courses in Ceará (Brazil) raises interest in resear-ch of aspects concerning them. This article investigates the bibliographical references used in master projects, by candidates who were submitted to the selection of a master degree in Psychology in a university located in Fortaleza, Ceará, in the period from 2006 to 2010. This is a bibliographic/documental research, whose collection consists of books and documents: sour-ces of study about Psychology - textbooks, psychology epistemology books, guide books - and fifty-two master projects. The books were used to define "basic authors" in the configuration of Psychological Science (psychological theories founders or recognized promoters of them). The references of the fifty-two master projects were analyzed and compared with those cited in the textbooks, psychology epistemology books and guide books. This allowed us identify the pro-portion between the use of "basic authors" and the use of authors, characterized as "emerging authors", those who begin to be referenced in scientific papers, but have not yet consolidated contributions to the development of psychology. The survey results show that candidates for the Psychology Graduate Program keep balance in the theoretical foundations of the projects. They use preferentially the "basic authors" of psychology and of the other sciences, but they also promote the emergence of new names in the scientific psychological, the "emerging authors".

Sujeitos da aprendizagem e tramas do ensino na contemporaneidade do ensino / Subject of learning and plots of teaching in contemporneity

Pesquisas, práticas docentes e reflexões pessoais realizadas durante os últimos anos dão ensejo a este trabalho que mostra as fraturas encontradas na prática docente-discente na universidade. As fraturas revelam a distância signifcativa entre a qualifcação teórica dos professores universitários - na sua maioria doutores - e os resultados que apresentam as avaliações que seus alunos obtêm no ENADE. Tal fenda se deve, em parte, à falta de preparação pedagógica dos professores. O texto traz reflexões sobre três temas, que embora diferentes, são complementares, a saber: a) o mal-estar na educação contemporânea, b) as vicissitudes dos sujeitos envolvidos no ensino e na aprendizagem (professores e alunos) e c) tramas no ensino superior entre distúrbios, difculdades e problemas de aprendizagem. Ciente da responsabilidade que nos outorga a profssão do magistério, os temas tratados no texto estão balizados na reflexão, na epistemologia e na ética, procurando que a prática docente seja cientifcamente excelente, intelectualmente reflexiva, socialmente comprometida e moralmente ética.(AU)

Research, teaching practices, and personal reflections made during the last few years give rise to this work that shows the fractures encountered in teacher-student practice in the university. Fractures reveal a signifcant gap between theoretical qualifcation of university professors - mostly doctors - and the results that the students obtain in the ENADE examinations. This slot is due in part to the lack of pedagogical preparation of teachers. The text reflects on three themes, which although different, are complementary, namely: a) the malaise in contemporary education, b) the vicissitudes of those involved in teaching and learning (teachers and students) and c) plot in superior level teaching, disorders, learning diffculties and problems. Aware of the responsibility that gives us the teaching profession, the topics covered in the text are marked in reflection, in epistemology and ethics, looking for that teaching practice is scientifcally excellent, intellectually reflective, socially committed and morally ethical.(AU)

Sarcoma de Ewing: epidemiologia e prognóstico dos pacientes tratados no Instituto de Oncologia Pediátrica, IOP-GRAACC-UNIFESP / Ewing's sarcoma: epidemiology and prognosis for patients treated at the Pediatric Oncology Institute, IOP-GRAACC-UNIFESP

OBJETIVO: Traçar o perfil epidemiológico e o prognóstico do sarcoma de Ewing na população brasileira. Material e MÉTODO: Foram avaliados, retrospectivamente, os prontuários de 64 pacientes tratados, com sarcoma de Ewing intraósseo, no Instituto de Oncologia Pediátrica, IOP-GRAACC-Unifesp, no período de 1995 a 2010. RESULTADOS: A análise estatística dos dados obtidos não correlacionou fatores como sexo, trauma, fratura patológica e tempo ao diagnóstico com o desfecho do tratamento. Fatores como metástase inicial, metástase pulmonar, local do tumor, idade, recidiva e tipo de cirurgia indicam resultados que corroboram a literatura consagrada. CONCLUSÃO: O prognóstico no sarcoma de Ewing foi influenciado principalmente pela presença de metástase ao diagnóstico.

OBJECTIVE: To outline the epidemiological profile and prognosis for Ewing's sarcoma in the Brazilian population. Material and METHODS: The medical records of 64 patients with intraosseous Ewing's sarcoma who were treated at the Pediatric Oncology Institute, IOP-GRAACC-Unifesp, between 1995 and 2010, were retrospectively evaluated. RESULTS: The statistical analysis on the data obtained did not correlate factors such as sex, trauma, pathological fracture and time taken for case diagnosis with the treatment outcome. Factors such as initial metastasis, lung metastasis, tumor site, age, recurrence and type of surgery showed results corroborating what has been established in the literature. CONCLUSION: The prognosis in cases of Ewing's sarcoma was mainly influenced by the presence of metastases at the time of diagnosis.

Evaluación del efecto hemostático de altas dinamodiluciones de Phosphorus en el paciente quirúrgico / Evaluation of hemostatic effect of wings dinamodiluciones of Phosphorus in the surgical patient

El estudio tiene por objeto demostrar el efecto del medicamento homeopático Phosphorus durante el procedimiento quirúrgico.

Análise sobre as emoções no livro Teoría de las emociones (Vigotski) / Analysis of the emotions in the book Teoría de las emociones (Vigotski)

O tratamento dado às emoções como objeto de investigação em psicologia transitou entre a negligência e a depreciação. Contudo, observamos atualmente o ressurgimento do interesse pelo estudo acerca dessa temática. Nesse contexto, consideramos pertinente retomar e discutir algumas contribuições de Vigotski concernentes às emoções. O presente trabalho buscou analisar aspectos apontados por Vigotski no manuscrito intitulado Teoría de las emociones - estúdio histórico-psicológico. Centramo-nos na crítica do autor ao dualismo que caracterizava tanto a teoria organicista das emoções (explicativa), quanto à apropriação puramente filosófica, idealista (descritiva) dessas. Discutimos ainda o possível entrave de cunho teórico-metodológico ao projeto de Vigotski de fundamentar a sua teoria nas contribuições do filósofo Espinosa: as divergências entre a perspectiva materialista histórico-dialética e o racionalismo/idealismo de Espinosa. Embora não tenha alcançado o seu objetivo de produzir uma teoria materialista-dialética das emoções, Vigotski inovou ao buscar integrar arte, ética e ciência em sua análise.

As a topic of research in psychology, emotions were treated with neglect and depreciation. However, we observe today a resurgence of interest in research of this topic. We consider it appropriate to retake and discuss some contributions of Vigotski related to emotions. This paper examined aspects pointed on the book Teoría de las emociones - estudio histórico-psicológico. He commented the dualism present in the organic theory of emotions (William James and Carl Lange). He also criticized the philosophical theories of emotions. We also pointed out the possible hindrance to support his theory of emotions on the contributions of the philosopher Spinoza: differences between the historical-dialectical materialist outlook and Rationalism-idealism of Spinoza. Although the goal of building a dialectical-materialist theory of emotion has not been reached, Vigotski innovated since sought to integrate art, ethics and science in his analysis.